The International Rett Syndrome Foundation is relentlessly pursuing a cure for Rett syndrome in the future while also providing unwavering support for families fighting Rett right now.

IRSF Has Been Changing the Game

IRSF Has Been Changing the Game

In our 38-year history, we have invested $54 million in Rett syndrome research.

Through the support of our donors, IRSF has been investing in projects that profoundly impact foundational Rett syndrome research, resulting in discoveries and partnerships critical to our mission of finding a cure. IRSF is advancing drugs and genetic approaches.
To find a cure for Rett syndrome, we have to give it everything we’ve got — for families, for children and for a future without Rett.

We’re ALL IN. No matter what it takes.

So we’ve set a bold goal: raise $29 million by 2024 to advance treatments and a cure for those with Rett syndrome.
We know this goal is possible, but not without your help.

Solutions for ALL

Rett is a complex disorder, and it shows up in many different ways. A one-size-fits-all approach to a cure would leave families around the world without hope. Your support empowers IRSF to continue our strategic pursuit of every promising lead to provide solutions for all.
Our three-pillar strategy:

Funding Critical Research

We carefully identify and fund game-changing, foundational Rett research, including the discovery of which gene causes Rett.

Creating a Robust Pipeline

We advance promising ideas from research to the therapeutic pipeline, accelerating solutions for every family battling Rett.

Ensure Clinical Trial Success

We collaborate with families, pharmaceutical companies, physicians and the FDA to eliminate obstacles to successful clinical trials.
Through our Center of Excellence Network, we’re ensuring care and therapies reach everyone living with Rett.

Go ALL IN With Us

Get Involved

Advocacy and raising awareness are crucial to supporting families, raising funds and finding a cure for Rett. See how you can help.

Donate

Help fund critical research that will provide hope and ultimately, a cure, for all individuals with Rett by donating today.

Join Us

Keep up with exciting updates on advances toward a cute and how you support is helping children with Rett thrive.

Sam & Sarah Ahlstrom, parents to Amanda

Sam & Sarah Ahlstrom,
parents to Amanda

The International Rett Syndrome Foundation continues to be a perfect one-stop-shop for us on our journey.

Thank God for IRSF, because if I didn’t have
IRSF, I would feel so alone and isolated.

ACADIA Pharmaceuticals

Thank you to the International Rett Syndrome Foundation (IRSF) and the entire Rett community who help make this research possible. We appreciate your continued partnership on this journey to find a treatment to address the core symptoms of Rett syndrome.

Julie Nguyen, mom to Sonia

Thank God for IRSF, because if I didn’t have IRSF, I would feel so alone and isolated.

In It Together

Together, we can raise $29 million by 2024 for advance treatments and a cure for those with Rett syndrome.
Together, we can raise $29 million by 2024 for advance
treatments and a cure for those with Rett syndrome.

IRSF Receives the
Highest Ratings

IRSF Receives the Highest Ratings